On the life and philosophy of Jiddu Krishnamurti, 1895-1986, Indian philosopher.

Precise and timely diagnosis of Parkinson’s disease is important to control its progression among subjects. Currently, a neuroimaging technique called dopaminergic imaging that uses single photon emission computed tomography (SPECT) with 123I-Ioflupane is popular among clinicians for detecting Parkinson’s disease in early stages. Unlike other studies, which consider only low-level features like gray matter, white matter, or cerebrospinal fluid, this study explores the non-linear relation between different biomarkers (SPECT + biological) using deep learning and multivariate logistic regression. Striatal binding ratios (...) are obtained using 123I-Ioflupane SPECT scans from four brain regions which are further integrated with five biological biomarkers to increase the diagnostic accuracy. Experimental results indicate that this investigated approach can differentiate subjects with 100% accuracy. The obtained results outperform the ones reported in the literature. Furthermore, logistic regression model has been developed for estimating the Parkinson’s disease onset probability. Such models may aid clinicians in diagnosing this disease. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

The Essay In This Book Deal With Such Topics As Silence As A Constituent Of Language, Justification Of Kant`S Antological Principles, Hegel`S Concept Of Reason, Total Man And The Role Of Revolution, A Meta-Physical Analysis Of Freedom, Dimensions Of Self-Expression, Love As A Form Of Authentic Expression, Radical Education In Institutionalized Surroundings Etc. In Honour Of S.N. Ganguly.

The section we have examined is a persuasive and sustained demolition of the realist strategy of deriving an invariable concomitance between the existenthood of the world and the system of validation (a system accepted by both parties as being the regulator of epistemic activity). This leaves the Advaitin with an absence of invariable concomitance. This is where the Advaitin wants to be. On his view, the absence of this concomitant dependence of the system of validation on an ‘existent’ world points (...) to the possibility that the cognized world is not that independent world which Nyāya takes to be the determinate reality. If that world is not philosophically proven to be so independent, then there is at least aprima facie case for the Advaitic soteriological claim that it is Brahman alone which is ultimately real, even though the commonly cognized world allows of coherent epistemic activity. It is fair to say that such a view is established by the failure of the opponent to prove invariable concomitance between inquiry, validation and an independent world. It is the inability of the opposing view to prove a metaphysical claim which itself points to the nature of the Advaitic position; the position, that is, which suspends the need to make an ontic commitment to the extrinsic world as a determinate reality. Whether the critique of the Nyāya concept ofsattā takes us to the refutation of the Nyāya concept of a determinate world (and whether the Advaitic rejection ofsattā is of a piece with the concept of an ‘indeterminate’ world) is another issue, dealt with in detail by Śrī Har $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s} $$ a elsewhere in his book, but beyond the purview of this paper. (shrink)

Objectives: Hospital ethics committees increasingly affect medical care worldwide, yet there has been little evaluation of these bodies. Israel has the distinction of having ethics committees legally required by a Patients' Rights Act. We studied the development of ethics committees in this legal environment.Design: Cross-sectional national survey of general hospitals to identify all ethics committees and interview of ethics committee chairpersons.Setting: Israel five years after the passage of the Patients' Rights Act.Main measurements: Patients' rights and informal ethics committee structure and (...) function.Results: One-third of general hospitals have an ethics committee, with committees concentrated in larger facilities. Hospitals without committees tended to lack any structure to handle ethics issues. Committees tend to be interdisciplinary and gender-mixed but ethnic mix was poor. Confidentiality is the rule, however, legal liability is a concern. One-third of patients' rights ethics committees never convened and most committees had considered fewer than ten consults. Access to the consultation process and the consultation process itself varied substantially across committees. Some patients' rights ethics committees attempted to solve cases, others only rendered decisions. Informal committees often refused to consider cases within Patients' Rights Act jurisdiction.Conclusions: Despite statutory requirement, many Israeli patients and clinicians do not have access to ethics committees. The scant volume of cases shows serious discrepancies between practice and Patients' Rights Act regulations, suggesting the need for education or revision of the law. Heterogeneity in committee function demonstrates need for substantial improvement. (shrink)

Biodiversity and Conservation 4: 916-928.

For Byzantium, the XIV century was the time of its last elevation in culture, which was called "Paleologic Renaissance." His main content was "hesychast disputes", which lasted for thirty years and took frequent political forms. The main subjects of this discussion were, on the one hand, the Calabrian monk Barlaam, who came from Italy, where he received Latin education, and on the other hand, the Thessalonian Metropolitan Gregory Palam, who spoke on behalf of the Athos monks. The followers of Palami (...) received the name "Palamit". Varlaam and Palama were representatives of two opposite directions in Byzantine culture of the XIV century. - "anti-knitting" and monastic-church. (shrink)

Исследование посвящено философскому осознанию природы духовности человека. Автор рассматривает духовность внутреннего мира человека как единство высших чувств души и нравственного сознания. Для специалистов в области философии, методологии науки.

The relations of such two important public institutions in Ukraine, as the state and the church, throughout national history, and especially in the era of independent state formation, have shown that they have always been a significant element of the climate formation in Ukrainian society, its spiritual potential and stability. Not always were these relations a priori constructive, but in their positive and negative ways they remained socially significant, determining the directions and tonality of many political, social and spiritual processes (...) of national history. 90s of the twentieth century. in the life of the Ukrainian society was marked by a radical change in the paradigm of being, which led to a rethinking of the whole spectrum of life-determining priorities and orientations - from political to cultural, world-view and religion. (shrink)